Disease-Modifying Serotonergic Innovation

At 2A Biosciences, we’re advancing serotonin 2A (5-HT2A) receptor science to develop disease-modifying therapies for neurodegenerative and inflammatory conditions.

Our platform combines deep expertise in GPCR biology with proprietary 3D models, advanced computational tools, and structure-activity insights.

We are advancing a portfolio of novel serotonergic therapies that:

  • Enhance anti-inflammatory, regenerative, and neuroprotective efficacy

  • Eliminate off-target and behavioral effects historically linked to 2A activation

  • Engineer key drug-like properties for ophthalmic and systemic delivery

Serotonin 2A Receptors are Instrumental to Good Health

Serotonin (5-HT) is a hormone more than a billion years old, orchestrating energy balance, metabolism, and cellular homeostasis. 5-HT2A receptors are the most widely expressed serotonin receptor, found throughout the brain and body.

Although the 5-HT2A receptor has received much attention in psychiatry over the last decade, our data reveal it to be a master regulator of inflammation and aging processes.

Supported by a growing body of research, 2A receptors are critical to health across many organ systems:

  • Regulates mood, cognition, memory, sleep, and neuroplasticity

  • Modulates heart function, vascular tone, hormone release, cellular adhesion and cytoskeletal dynamics, gut motility and gut-brain signaling, immune responses, and tissue regeneration

Targeting Eye & Brain Neurodegeneration

Most neurodegeneration treatments target a single pathway and fail to stop disease progression.

By activating upstream 2A receptors, our platform enables two synergistic therapeutic strategies, simultaneously altering multiple disease pathways. The result: disease modification.

Our proprietary small molecules precisely activate 2A receptors, addressing disease at the root:

  • Halts nerve degradation, regenerates nerves, and restores functional recovery

  • Shields neuronal cells from ongoing stress, disease progression, and death

  • Heals chronic inflammation and restores homeostasis

Differentiated Safety and Tolerability

Unlike immunosuppressive or broadly acting treatments, our serotonergics promote homeostasis without generalized immunosuppression.

Preclinical studies confirm exceptional safety and tolerability, with no adverse effects detected in animal models — underscoring our commitment to safe, patient-centric innovation.