Serotonergic Innovation

Our platform combines deep expertise in GPCR biology with proprietary 3D models, advanced computational tools, and structure-activity insights — leading to a portfolio of enhanced serotonergic assets, and advancing the field of serotonin 2A receptor science.

Safe, Tolerable, & Effective

  • Enhanced anti-inflammatory and regenerative efficacy

  • Eliminated off-target and hallucinogenic effects historically linked to 2A activation

  • Engineered key drug-like properties for indication specific delivery, safety, and tolerability

    (ophthalmic, brain-penetrant, systemic)

Our therapies promote homeostasis without generalized immunosuppression, unlike standard broadly acting treatments. They also drive endogenous system and functional repair, unlike exogenous standards of care.

Preclinical studies confirm exceptional safety and tolerability, with no adverse effects detected in animal models — underscoring our commitment to safe, patient-centric innovation.

Serotonin 2A Receptors are Instrumental to Good Health

Serotonin (5-HT) is a hormone more than a billion years old, orchestrating energy balance, metabolism, and cellular homeostasis. 5-HT2A receptors are the most widely expressed serotonin receptor, found throughout the brain and body.

Although the 5-HT2A receptor has received much attention in psychiatry over the last decade, data demonstrate it to be a master regulator of inflammation and aging processes throughout the body.

Supported by a growing body of research, 2A receptors are critical to health across many organ systems:

  • Regulates mood, cognition, memory, sleep, and neuroplasticity

  • Modulates heart function, vascular tone, hormone release, cellular adhesion and cytoskeletal dynamics, gut motility and gut-brain signaling, immune responses, and tissue regeneration

First Targeting Ocular Neurodegeneration

Most neurodegeneration treatments target a single pathway and fail to stop disease progression or drive durable repair.

Our proprietary small molecules enable simultaneous, synergistic therapeutic strategies through precise, upstream 2A receptor activation:

  • Halts nerve degradation, regenerates nerves, and restores functional recovery

    Regenerated corneal nerves in multiple species and animal models of corneal injury

  • Shields neuronal cells from ongoing stress, disease progression, and death

    Protected retinal ganglion cell (RGC) dropout in animal model of glaucoma-driven ocular neurodegeneration

  • Heals chronic inflammation and restores homeostasis

    Resolved inflammation and protected against neuroinflammation-related death in animal models of virus-induced ocular inflammation