Disease-Modifying Serotonergic Innovation
At 2A Biosciences, we’re advancing serotonin 2A (5-HT2A) receptor science to develop disease-modifying therapies for neurodegenerative and inflammatory conditions.
Our platform combines deep expertise in GPCR biology with proprietary 3D models, advanced computational tools, and structure-activity insights.
We are advancing a portfolio of novel serotonergic therapies that:
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Enhance anti-inflammatory, regenerative, and neuroprotective efficacy
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Eliminate off-target and behavioral effects historically linked to 2A activation
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Engineer key drug-like properties for ophthalmic and systemic delivery
Serotonin 2A Receptors are Instrumental to Good Health
Serotonin (5-HT) is a hormone more than a billion years old, orchestrating energy balance, metabolism, and cellular homeostasis. 5-HT2A receptors are the most widely expressed serotonin receptor, found throughout the brain and body.
Although the 5-HT2A receptor has received much attention in psychiatry over the last decade, our data reveal it to be a master regulator of inflammation and aging processes.
Supported by a growing body of research, 2A receptors are critical to health across many organ systems:
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Regulates mood, cognition, memory, sleep, and neuroplasticity
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Modulates heart function, vascular tone, hormone release, cellular adhesion and cytoskeletal dynamics, gut motility and gut-brain signaling, immune responses, and tissue regeneration

Targeting Eye & Brain Neurodegeneration
Most neurodegeneration treatments target a single pathway and fail to stop disease progression.
By activating upstream 2A receptors, our platform enables two synergistic therapeutic strategies, simultaneously altering multiple disease pathways. The result: disease modification.
Our proprietary small molecules precisely activate 2A receptors, addressing disease at the root:
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Halts nerve degradation, regenerates nerves, and restores functional recovery
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Shields neuronal cells from ongoing stress, disease progression, and death
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Heals chronic inflammation and restores homeostasis
