Advancing Breakthrough Medicines
Harnessing Serotonin 2A Biology for Regeneration and Inflammation Resolution
Precision Serotonergic Therapies
Serotonin 2A receptors - long misunderstood as purely psychotropic - are now known to be powerful modulators of neuroregeneration, mitochondrial biogenesis, and inflammation.
Through precise molecular designs, our proprietary non-hallucinogenic small molecules activate serotonin 2A receptors to unlock regenerative and anti-inflammatory outcomes.
2A Biosciences aims to transform treatment for the 400M+ people globally suffering from degenerative and chronic inflammatory diseases, starting with neurodegenerative eye diseases.
Our lead program is on track to enter Phase 2a trials in Q4 2026.
Backed by Established Science
Serotonin, Immune Function, and Psychedelics as Potent Anti-Inflammatories
Charles D. Nichols, Timothy P. Foster
From Psychiatry to Neurology: Psychedelics as Prospective Therapeutics for Neurodegenerative Disorders
Urszula Kozlowska, Charles D. Nichols, Kalina Wiatr, Maciej Figiel
Psychedelics and Anti-Inflammatory Activity in Animal Models
Thomas W. Flanagan, Charles D. Nichols
5-HT2A receptors: Pharmacology and Functional Selectivity
Benjamin R. Cummins, Gerald B. Billac, David E. Nichols, Charles D. Nichols
History of Psychedelic Drug Science and Molecular Pharmacology
David E. Nichols, Charles D. Nichols
The Structural Diversity of Psychedelic Drug Actions Revealed
Ryan H Gumpper, Manish K Jain, Kuglae Kim, Renhong Sun, Ning Sun, Zhongli Xu, Jeffrey F DiBerto, Brian E Krumm, Nicholas J Kapolka, H Ümit Kaniskan, David E Nichols, Jian Jin, Jonathan F Fay, Bryan L Roth
